Everyone deserves to know their baseline risk for disease.
Polygenic risk scores are tools for assessing an individual's risk of developing a specific disease. Combining genomic data and statistical modeling, polygenic risk scores have the potential to advance complex disease understanding and precision medicine.
Coronary artery disease¹
Type 2 diabetes²
Breast cancer⁴
Psychiatric conditions, like bipolar disorder⁵
Heart failure⁷
Laboratory / Test Information
Strand’s sequencing is conducted at a leading US-based precision medicine laboratory, certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists (CAP). We ensure that all data remains within the United States, safeguarded by stringent privacy and security protocols that fully comply with HIPAA regulations to protect your personal health information.
References
Marston NA, Pirruccello JP, Melloni GE, et al. Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention. JAMA Cardiol. 2023;8(2):130-137. doi: 10.1001/jamacardio.2022.4466
Khera AV, Chaffin M, Aragam KG, et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018;50(9):1219-1224. doi: 10.1038/s41588-018-0183-z
Wong CK, Makalic E, Dite GS, et al. Polygenic risk scores for cardiovascular diseases and type 2 diabetes. PLoS One. 2022;17(12):e0278764. doi: 10.1371/journal.pone.0278764
Pharoah PD, Antoniou AC, Easton DF, Ponder BA. Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med. 2008;358(26):2796-803. doi: 10.1056/NEJMsa0708739
Liebers DT, Pirooznia M, Ganna A; Bipolar Genome Study, Goes FS. Discriminating bipolar depression from major depressive disorder with polygenic risk scores. Psychol Med. 2021;51(9):1451-1458. doi: 10.1017 S003329172000015X.
Mao Q, Lan Z, Liu P, et al. Applications of Polygenic Risk Scores in Psychiatric Genetics. EC Psychol Psychiatr. 2023;12(4):19-21.
Lanfear DE, Luzum JA, She R, et al. Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank. Circ Genom Precis Med. 2023;16(2):e003835. doi: 10.1161/ CIRCGEN.121.003835
